Moreover, A allele of rs1143627 was significantly associated with breast cancer as a protective effect and gastric cancer as a risk factor, but the IL‐1B rs1143627 polymorphism was no influence on non‐small cell lung cancer clinical outcomes (Chang et al., 2005; Ito et al., 2002; Perez‐Ramirez et al., 2017). This evidence concerns the gene IL1B and breast cancer.