TGFB1 and neoplasm: On one hand, TGF‐β mediated signals and the interaction between cells are confirmed to provide a favorable microenvironment for tumor metastasis and progression.126 It largely depends on the effect of remodeling tumor microenvironment (such as ECM, cells distribution and cytokines secretion) and regulating the interactions with other cells which express TGF‐β receptors (TGF‐BR).