NFKB1 and cancer: For instance, NF‐κB, has been shown to initiate tumor progression by elevating the production of reactive oxygen and nitrogen species.54 It is also considered as an important signals to stimulate tumor initiation by producing the mutator enzyme activation‐induced cytidine deaminase.116 In fact, the major effect of NF‐κB on tumorigenic is to promote cancer cells proliferation and inhibit apoptosis.117, 118