In addition, PD‐L1 and PD‐L2, which were expressed in TAMs, are considered to be mediated by IL‐27 induced STAT3 signaling pathway as well.123 Generally, the cytokine mediated STAT3 gives rise to a high expression of genes that involved in proliferation, survival, antiapoptotic, and immune suppression of cancer cells. The gene discussed is STAT3; the disease is cancer.