In this process, the matrix metalloproteinase (MMPs) synthesis which have a significant impact on angiogenesis is regulated by vascular endothelial growth factor (VEGF), platelet derived growth factor (PDGF), fibroblast growth factor (FGF), and TGF‐β.10, 11, 12 As reported recently, TAMs have a special transition period from M1‐like to M2‐like phenotype, which means they are not just belonging to M1‐like or M2‐like phenotype at the whole process of tumor progression. Here, TGFB1 is linked to neoplasm.