VEGF is well known to stimulate angiogenesis and then provide nutrient for tumor growth.101 PDGF, as the most important growth factor for pericytes, contribute to angiogenesis by stimulating pericytes.102 FGF has been confirmed to increase the gene expression of VEGF receptors and accelerate the proliferation of endothelial cells and fibroblasts, thus promoting angiogenesis further. This evidence concerns the gene VEGFA and neoplasm.