They build a communication between innate immunity and adaptive immunity, and plays a critical role in the specific immunity.25, 26 They are also an important component in various tumor microenvironments and regulated significantly by IL‐10, VEGF and prostaglandin E2 (PGE2).27, 28, 29, 30 In general, the role of DCs in tumor development is controversially. This evidence concerns the gene IL10 and neoplasm.