NFKB1 and cancer: Herein, it is worth noting that the NF‐κB is silent in normal cells but active in cancer cells, and can always be activated by the proinflammatory cytokines from both cancer cells and immune cells.114, 115 In current opinion, the mechanism of NF‐κB dependent tumor progression can be concluded as follows: the gene expression of VEGF and IL‐8 become abnormal and the transcription of MMPs become active in angiogenesis process, both of which will accelerate ECM degradation and the cancer cells invasion to surrounding tissue.