CXCL12 and neoplasm: Moreover, the primary TAMs can recruit monocytes to tumor site by secreting chemotactic factors of CCL2, CCL5, CCL7, CXCL8 and CXCL12 which can be polarized to M2‐like phenotype with the stimulation of IL‐4, IL‐6, IL‐10, IL‐13 and transforming growth factor‐beta (TGF‐β).8, 9 Besides, products of tumor‐promoting growth factors from TAMs, such as epidermal growth factor (EGF), also make efforts to neovascularization and modulating immune response.