We also demonstrated that BZP inhibited excessive autophagic activity both in vitro and in vivo (Figures 2 and 6), ameliorated cardiomyocyte hypertrophy (Figure 3), alleviated TAC‐induced cardiac hypertrophy and dysfunction (Figures 4 and 5), and suppressed autophagy via suppressing the AMPK‐mTOR signalling pathway (Figure 7). This evidence concerns the gene MTOR and cardiac hypertrophy.