We found that BZP could inhibit angiotensin II (Ang II)‐induced cardiomyocyte hypertrophy and excessive autophagy through AMP‐activated protein kinase (AMPK)‐mammalian target of rapamycin (mTOR) signalling and could ameliorate pressure overload‐induced cardiac hypertrophy and heart dysfunction. The gene discussed is AGT; the disease is cardiac hypertrophy.