Some previous studies reported that PDLIM2 expression was also regulated by the promoter methylation that blocks its transcription in colon cancer,26 ovarian cancer28 and classical Hodgkin and anaplastic large cell lymphoma.29 However, whether its expression is related to the methylation status of its promoter in ESCC is still not clear. This evidence concerns the gene PDLIM2 and esophageal squamous cell carcinoma.