PDLIM2 belongs to the actinin‐associated LIM family of proteins and participate in the cellular processes such as cell differentiation and cytoskeleton organization as it interacts with α‐actinin‐1, α‐actinin‐4, filamin A and myosin heavy polypeptide 9 in epithelial cells.19, 20 In addition, it acts as ubiquitin E3‐ligase that induces the inactivation and degradation of STAT1, STAT3 and STAT4, thereby negatively regulates STAT signalling pathway hemopoietic cells.21, 22 Previous studies found that PDLIM2 had both tumour suppressive and oncogenic effects in different malignancies. This evidence concerns the gene STAT3 and neoplasm.