NR5A1 can bind to the promoters of many LC‐specific genes such as Star, Cyp11a1, Cyp17a1 and Hsd3b1. 51, 52, 53, 54 Null mutation of NR5A1 caused LC agenesis.55 Forced expression of NR5A1 can even convert stem cells or fibroblasts into steroidogenic LC‐like cells by transcriptionally promoting the expression of LHCGR and other steroidogenic enzymes (CYP11A1, HSD11B1, CYP17A1 and HSD17B3).56 The gene discussed is HSD11B1; the disease is laryngotracheoesophageal cleft.