RDM1 and breast carcinoma: Cells have various DNA damage response pathways that respond to DNA insults and thereby maintain genomic stability.17, 18 Numerous studies have indicated that the DNA damage response acts as an intrinsic barrier to the initial phases of tumorigenesis in humans19 and that it is frequently altered in human malignancies.20 In this study, we identified RDM1 as a novel oncogenic protein in breast cancer progression.