In the present study, we demonstrated that suppression of 14‐3‐3ζ expression strongly retarded the growth of Hep‐2 laryngeal cancer cells, concomitant with the occurrence of the senescence phenotype, as evidenced by an increase in senescence‐specific SA‐β‐gal staining‐positive cells and by accumulation of PML‐NB (Figure 2E,F). Here, PML is linked to laryngeal carcinoma.