However, the 5 mg/kg/d dose improved well‐being and quality of life scores.18 The remaining studies are case studies in which CBD decreased psychotic symptoms and Parkinson's disease ratings (n = 6; 7 mg/kg/d),31 improved rapid eye movement sleep behaviour disorder (n = 4; 1 mg/kg/d),37 decreased dyskinesia with 2 to 3 mg/kg/d doses (n = 1), but exaggerated Parkinson's disease symptoms with 5 and 7 mg/kg/d doses.42 The gene discussed is OPN1MW; the disease is Parkinson disease.