Notably, survival rate of oral cancer patients with co-expression level of low HSPD1/low E-cadherin is higher than those with co-expression level of high HSPD1/high E-cadherin from TGCA cohort (Fig. 5G), which is opposite to the findings in our cohort study (Fig. 5D–F). The gene discussed is HSPD1; the disease is lip and oral cavity carcinoma.