In our recently published work, we found that the methylation-dependent suppression of Tissue Factor (TF) contributes to the reduced thrombogenicity and reduced malignancy of IDHmut gliomas, and that methylation and suppression of the gene encoding TF, F3, is far greater in IDHmut gliomas than in other IDHmut cancers18,19. The gene discussed is F3; the disease is glioma.