Our results show that the HbA1c-associated miR-181a-2-3p, -146b-5p, -148a-3p, and -221-3p, and hsa-let-7a and miR-589-3p, were also independently and significantly (p < 0.05) associated with mRNA levels of the insulin signaling pathway and type 2 diabetes pathway genes (Fig. 2A,B, Supplementary Tables S6 and S7). The gene discussed is INS; the disease is type 2 diabetes mellitus.