When analyzing the co-regulation of the miRNAs of interest in the insulin signaling pathway and Type 2 diabetes mellitus pathway, we were able to see a significant correlation between hsa-miR-146-5p and its predicted target PRKAG2, a part of the AMP-activated protein kinase and a major cellular regulator of lipid and glucose metabolism. The gene discussed is PRKAG2; the disease is type 2 diabetes mellitus.