To investigate the role of bioactive lipids in lupus, we analysed the concentrations of various CYP products and metabolites (see Supplementary Fig. 1 for a full list of metabolites) in the kidneys of lupus prone NZB/W F1 mice (n = 6, prenephritic NZB/W F1; n = 5, nephritic NZB/W F1) and the healthy C57BL/6NCRL (n = 7) mouse strain (cumulative data in Fig. 1; separated data in Supplementary Fig. 2). This evidence concerns the gene PPIG and systemic lupus erythematosus.