FOXF2 and breast carcinoma: To further verify the role of the BMP/SMAD signaling pathway in mediating the promotion of breast cancer bone-specific metastasis by FOXF2, we established stable MDA-MB-231 cells with FOXF2 overexpression (231-FOXF2) or vector control (231-Vector) via lentiviral infection for mouse xenograft experiments by ventricle injection.