NLRP3 and Sepsis: Mortality was not the only late-outcome associated with early NLRP3-immunocompromised septic patients, for example, the evolution of clinical parameters, such as ΔSOFA (calculated as the change in SOFA from day 1 to day 5) increased in these patients (Fig. 2g, Supplementary Table 4), thus confirming that ΔSOFA is an accurate late-prognostic marker for sepsis-related deaths30, while profound NLRP3 immunoparalysis emerged as a potential early prognostic marker.