There were also no differences in plasma cytokines, monocytes with active caspase-1, circulating ASC-specks (Supplementary Fig. 2h), or infection type among septic patients with profound NRLP3 immunosuppression (Supplementary Tables 2 and 5), although NLRP3-immunocompromised patients suffered more often from nosocomial infection (Supplementary Table 2). Here, CASP1 is linked to infection.