In contrast to IgE, endotoxin concentration was decreased in the asthmatic subjects (P value = 0.0650), and there appeared to be an inverse correlation between circulatory endotoxin levels and the reporting of additional atopic complications with those patients with more conditions from the eosinophilic triad, having lower levels than those patients with asthma alone and the control patients. The gene discussed is IGHE; the disease is asthma.