One explanation is that JARID1C represses important oncogenic target genes by reducing the active H3K4me3 marks at several promoters, where it is recruited via interactions with DNA-binding proteins64; furthermore, JARID1C is recruited to the promoters of IGFBP1, DNAJC12, COL6A1, and GDF15 by interacting with HIF in 786-O VHL−/− ccRCC cells60, and at the long control region promoter of the viral E6 and E7 genes via interaction with E262. This evidence concerns the gene KDM5C and nonpapillary renal cell carcinoma.