VHL and nonpapillary renal cell carcinoma: One explanation is that JARID1C represses important oncogenic target genes by reducing the active H3K4me3 marks at several promoters, where it is recruited via interactions with DNA-binding proteins64; furthermore, JARID1C is recruited to the promoters of IGFBP1, DNAJC12, COL6A1, and GDF15 by interacting with HIF in 786-O VHL−/− ccRCC cells60, and at the long control region promoter of the viral E6 and E7 genes via interaction with E262.