Several studies have consistently shown that JARID1C and UTX function as tumor suppressors in various cancers, whereas the other isoforms, JARID1A, 1B, and 1D of the KDM5 subfamily and JMJD3 of the KDM6 subfamily, function as tumor suppressors and oncogenes, depending on the cancer type. This evidence concerns the gene KDM6B and cancer.