The results suggest that the SNP rs4783099 in CRISPLD2 may contribute to an increased risk of NSCPO, and the SNP rs2237138 in JARID2 may hold a protective effect against non-syndromic cleft lip with or without cleft palate (NSCL ± P), in the Brazilian population. The gene discussed is CRISPLD2; the disease is cleft palate.