Further pathway analysis of the microarray data set using Ingenuity20, and Consensus Path DB21 pathway tools revealed enrichment of many immune-related pathways in response to the CDT expressing strain, including many tissue-regulatory pathways, including IL-10R, IL-4, and IL-13 (Supplementary Fig. 1e; Fig. 1d). This evidence concerns the gene IL4 and isolated focal cortical dysplasia type II.