EGFR and lung adenocarcinoma: The upregulated serine metabolism was further confirmed in 740 lung adenocarcinoma patients extracted from the TCGA database by comparing EGFR mutated cancer patients (n = 25) with the rest wildtype EGFR tumors (n = 715) (Fig. 2a), suggesting that SSP could be a clinically-relevant vulnerability for this subtype of cancer.