PC9 xenograft model (Fig. 2d) and a NSCLC patient-derived xenograft (PDX) model LU-01-0251 with EGFR L858R mutation (Fig. 2e, Supplementary Dataset 7) were treated with EGFR inhibitor Gefitinib or NCT503, the only PHGDH inhibitor reported to exhibit in vivo activity. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.