It was notable that AKR1B10 expression in human breast cancers positively correlated with the key FAO transcriptional regulator, peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PPARGC1A, also known as PGC-1α) (P = 0.009) and negatively correlated with the activators for fatty acid synthesis, acetyl-CoA carboxylase β (ACACB; P = 0.047) and acyl-CoA synthetase long chain family member 1 (ACSL1; P < 0.001), Spearman’s correlation. This evidence concerns the gene PPARGC1A and breast cancer.