PPARGC1A and neoplasm: Moreover, by analysing multiple breast cancer clinical data sets, Camarda and colleagues have demonstrated dysregulation of fatty acid metabolism genes in triple negative (TN) compared to receptor positive breast cancers and, in particular, increased expression of key activators of FAO, such as PGC-1α (PPARGC1A) and decreased expression of genes encoding regulators of fatty acid synthesis33, a pattern demonstrated here to be recapitulated in AKR1B10High tumours.