Interestingly, analysis of genes that are associated with endothelial cell function showed that a number were significantly increased in angiosarcomas in both the human and mouse datasets (VEGFC, EPHA2), whereas others were differentially regulated in the human and mouse angiosarcomas (VEGFA, VEGFB, KDR, MYC) (Fig. 6D). The gene discussed is EPHA2; the disease is angiosarcoma.