Using Ai14 reporter mice (single-fluorescent reporter mice that express tdTomato after Cre-mediated recombination) (Madisen et al., 2010), we found that Pdgfrb-Cre induced highly efficient recombination in mouse skin (Fig. 3A), a tissue in which a number of angiosarcomas arose in the Pdgfrb-Cre, Trp53R172H/R172H mice. Here, PDGFRB is linked to angiosarcoma.