PDGFRB and angiosarcoma: Analysis of Pdgfrb-Cre mice has shown that recombination occurs in a number of cell types during development, including endothelial and mural cells (Stanczuk et al., 2015; Ulvmar et al., 2016), so it is not possible to define the cell of origin in the angiosarcomas that developed in the Pdgfrb-Cre, Trp53R172H/R172H mice.