mTORC1 pathway activation has also been reported in human angiosarcomas (Sun et al., 2015; Chadwick et al., 2018) and has been linked to Myc-mediated transcriptional regulation of VEGFA (Sun et al., 2015); increased expression of both Myc and Vegfa in the angiosarcomas from the Cdh5-CreERT2, Trp53fl/fl mice suggest that a similar autocrine stimulation loop may be present in these tumours, although the involvement of mTORC signalling in these tumours is not known. The gene discussed is CDH5; the disease is angiosarcoma.