By contrast, an increasing number of studies have reported copy-number alterations, increased phosphorylation or misexpression of individual RTKs in chordoma, most prominently of EGFR, KDR, PDGFRA, KIT and of different FGFR genes (Akhavan-Sigari et al., 2014a,b,c; de Castro et al., 2013; Dewaele et al., 2011; Fischer et al., 2015; Launay et al., 2011; Miettinen et al., 2012; Tamborini et al., 2006). Here, KDR is linked to chordoma.