In particular, the striking consistency of TBXT expression in chordoma has gathered increasing attention as a tumor-defining and possibly causative characteristic, pointing at the re-activation or maintenance of the embryonic notochord program as the cause (Nelson et al., 2012; Presneau et al., 2011; Szuhai and Hogendoorn, 2012; Yang et al., 2009). This evidence concerns the gene TBXT and neoplasm.