We further tested the tumorigenic potential of STAT3 involved in JAK/STAT signaling, as positive staining for STAT3 and phospho-STAT3 have been repeatedly reported in human chordoma (Dobashi et al., 2007; Tauziède-Espariat et al., 2016; Yang et al., 2010). The gene discussed is STAT3; the disease is chordoma.