Genomic sequencing of patient chordoma samples continues to uncover mutated genomic loci including PTEN (Choy et al., 2014), the tuberous sclerosis complex (TSC) genes (Han et al., 2009), TP53 (Pallini et al., 2003) and BCL6 (Rinner et al., 2013). This evidence concerns the gene BCL6 and chordoma.