However, de novo activating mutations in the STING molecule have also been identified as being responsible for a monogenic autoinflammatory syndrome (Jeremiah et al, 2014; Chia et al, 2016; Fremond et al, 2016; Picard et al, 2016; Konig et al, 2017) known as SAVI (Liu et al, 2014). This evidence concerns the gene STING1 and autoinflammatory syndrome.