Key inclusion criteria were as follows: (1) advanced or metastatic, pathologically diagnosed NSCLC with measurable tumor lesion by Response Evaluation Criteria In Solid Tumors (RECIST) version 1.1; (2) received at least two lines of prior chemotherapy, with wild-type epidermal growth factor receptor (EGFR) or anapastic lymphoma kinase (ALK), or sensitive mutations but failed in relevant targeted therapy; (3) ECOG 0 or 1. The gene discussed is EGFR; the disease is neoplasm.