Basic experimental research also showed that MET phosphorylation levels and glioblastoma tumor growth are reduced by the expression of HAI-2 both in vitro and in intracranial xenografts in nude mice, and that HAI-2 suppresses fibrinolytic activities and inhibits the Matrigel invasion of glioblastoma cell lines [48, 49]. The gene discussed is SPINT2; the disease is glioblastoma.