Despite its brief history, dozens of studies have evaluated the diagnostic value of [TIMP-2]•[IGFBP7] for AKI, in various settings (e.g., cardiac surgery, ICU, emergency department/trauma), different patient populations (e.g., KDIGO criteria, elderly, high-risk surgeries), and measurement criteria (e.g., thresholds, sampling times). This evidence concerns the gene IGFBP7 and acute kidney injury.