APOE and Alzheimer disease: The overall purpose of this study was to examine the relationships of both level (at a statistical centering age) and slope (longitudinal change) between frailty and three cognitive domains: (a) episodic memory, (b) neurocognitive speed, and (c) executive function (EF) as moderated by two non-modifiable risk factors for AD (i.e., sex and APOE genetic risk).