Indeed, PD-L1-specific HTLs showed higher cytotoxic activity against IFN-γ-pretreated tumor cell lines than untreated tumor cell lines in vitro and intratumoral treatment of IFN-β did not negatively affect the function of PD-L1-specific HTLs for inhibiting tumor growth in vivo. The gene discussed is IFNB1; the disease is neoplasm.