LNC-LBCS and posterior cortical atrophy: Consistent with Cohort 1, we observed that the LBCS expression was significantly downregulated in PCa compared with BPH tissues (Fig. 1i), in tissues with Gleason Score of 8–10 compared with 6–7 (Fig. 1j), in T3–4 tumors compared with T2 (Fig. 1k, Additional file 9: Figure S1C-D).