Collectively, these results indicate that GBE1 blockade induces IFN-I production via STING signaling pathway, accompanied by upregulation of PD-L1 in LUAD cells, which further enhances the secretion of CCL5 and CXCL10 to recruit CD8+ T lymphocytes in the tumor microenvironment. Here, GBE1 is linked to neoplasm.