Several of the predicted PI3K target genes were further examined by qRT-PCR, of these CXCL10 was found to be specifically elevated in high BMI control subjects, whereas HMOX1 and SREBF1 were decreased both in high BMI control subjects and in low BMI subjects with idiopathic gastroparesis (Additional file 1: Figure S1). The gene discussed is CXCL10; the disease is gastroparesis.