Although, most knowing biomarkers, like PD-L1, IFN-γ, IFN-γ associated immune gene signature, TGFβ/Wnt-β-catenin signaling, and CD8 T cells infiltration could be identified from the globe expression of MSI subtype colon cancer patients, some biomarkers may be not involved in MSI expression signature. Here, CD274 is linked to malignant colon neoplasm.