IGFBP3 and colitis: The plasma IGFBP3 concentrations were significantly different among the three groups at d3 and d5 (F = 13.22, P < 0.001; F = 24.76, P < 0.001) and were significantly lower in both the colitis and pair-fed groups than those in the control group (P < 0.05) (Fig. 4).