At d3 and d5, the plasma IGFBP2 concentrations were significantly different among the three groups (F = 19.90, P < 0.001; F = 15.80, P < 0.001) and were significantly higher in both the colitis and pair-fed groups than those in the control group (P < 0.05). This evidence concerns the gene IGFBP2 and colitis.