There were significant differences in the colonic MPO concentrations among the three groups at d3 and d5 (F = 34.49, P < 0.001; F = 23.67, P < 0.001), and the colonic MPO concentrations in the colitis group were higher than those in the control group or pair-fed group (P < 0.01) (Fig. 2). The gene discussed is MPO; the disease is colitis.