ESR1 and hydrops fetalis: There are two reasons: one is all of them were emphasized during stage transitions of cashmere growth in skins by researchers before [2, 5]; the other is corresponding hormone-binding receptors (i.e., ESR1, IGTAV and LEPR) were on the list of upregulated genes, which strongly suggests goat DPCs are targets of estrogen, thyroid hormone, and leptin in the HF.