We recently demonstrated that Ras homolog enriched in brain is a GTP-binding protein (Rheb), an upstream activator of the mechanistic target of rapamycin (mTOR), serves as a key negative regulator of beige fat thermogenesis, and plays a role in high-fat diet (HFD)-induced insulin resistance (Meng et al., 2017). This evidence concerns the gene MTOR and Insulin resistance.