Various deletions and duplications of the short and long arm of the X chromosome are also found in women with primary ovarian insufficiency, with several genes implicated, including fragile X mental retardation 1 (FMR1), premature ovarian failure 1B (POF1B), diaphanous related formin 2 (DIAPH2), forkhead box L2 (FOXL2), and bone morphogenetic protein 15 (BMP15) (111). This evidence concerns the gene FOXL2 and Premature ovarian insufficiency.