SAMHD1 and infection: However, CCR6+DN were more abundant in SAMHD1+ than in SAMHD1low (25.6% vs 8% and 14.7% vs 3.8%, respectively), which let us hypothesize that it might be partly due to high SAMHD1 expression, consistent with its role as a restriction factor that inhibits viral life cycle and cell infection and depletion [26–29].