However, there remained a significant increase in CD3 T cells in infected animals (p = 0.0407), which was entirely driven by a robust expansion of CD8 T cells (Fig 4B; p = 0.0011), with a dominant and significant increase in Tem CD8 cells (Fig 4C; p<0.0001), and a stronger skewing towards SLECs (p<0.0001) over MPECs (p = 0.0069) compared to the acute (7d p.i) infection (Fig 4D). The gene discussed is CD8A; the disease is infection.