ACTN4 and IgA glomerulonephritis: Similarly, in IgA nephropathy the log10 mRNA expression of alpha-actinin-4 (p = 0.001), podocin (p = 0.012), and podocalyxin (p = 0.02) was significantly higher, but, for the profibrotic factors, there was no significant difference (p>0.05).