MYBPC3 and hypertrophic cardiomyopathy: Along similar lines, across a total of 2,459 patients at different ages and 53 families, the presence of a mutation in a sarcomere gene (cardiac myosin-binding protein C gene [MYBPC3] and myosin heavy chain 7 gene [MYH7]) in familial hypertrophic cardiomyopathy (HCM) has been associated with a number of phenotypic clinical features, including age at presentation, gender, family history of familial HCM and sudden cardiac death (SCD), and maximum left ventricular wall thickness (MLVWT) [95].