HLA-C and neoplasm: In addition, for both the neoepitope and WT peptides, the polar side chains at P4 (glutamine) and P7 (histidine) are predicted to face upwards toward incoming T cell receptors in approximately the same orientation, which might explain the lack of anti-tumor activity of the KYLQVASHV neoepitope despite the improved peptide-MHC binding affinity.