TRPM7 and pulmonary arterial hypertension: Motivated by these clues and the previously reported involvement of TRPM7 in promoting vascular proliferation, we aimed to investigate whether TRPM7 has a clinical relevance to PAH and explore its possible functional role and underlying mechanisms in influencing PAH features in vitro and in vivo conditions by utilizing the cultured PASMCs and a rat model with hypoxia-induced PAH.