ESR1 and breast carcinoma: Our results showed that QYFE only significantly induced the viability of MCF-7 cells and no influence on the ER-negative MDA-MB-231 cells, QYFE is more sensitive to ER-positive MCF-7 human breast cancer cells (Figure 7), which indicates the induced of MCF-7 cell proliferation by QYFE maybe mediated by ER.