To verify the inhibitory effect of losartan on CXCR4, we treated MDA-MB-231 cells with SDF-1α and found that SDF-1α-treated tumor cells showed a distinct cytoskeletal redistribution of F-actin stress fibres and lamellipodia formation beginning 20 min after SDF-1α exposure by phalloidin staining. Here, CXCL12 is linked to neoplasm.