There is evidence that in certain cancer types, such as gastric cancer, ovarian cancer, lung cancer and choriocarcinoma, Ang II/AGTR1 signaling is associated with the upregulation of a range of target genes that play a role in MMP-2 and MMP-9 activation and the induction of ICAM-dependent adhesion, inducing cell migration and EMT. This evidence concerns the gene MMP2 and choriocarcinoma.