A growing number of chemokine ligands and their receptors, including CCL19 and CCL21 for CCR7, CXCL13 for CXCR5, CCL1 for CCR8 [12, 13] and CXCL12 (also known as SDF-1α) for CXCR4, have been demonstrated to attract tumor cells to lymph nodes. Here, CXCR4 is linked to neoplasm.