Quantification of AGTR1 by the HSCORE method (shown in Figure 1B) suggested a significant increase in its expression in breast cancer tissues with lymph node metastasis (2.16 in LN+ vs. 1.52 in LN-), while similar results were observed in ER+ or HER2- samples (Supplementary Figure 1). This evidence concerns the gene ERBB2 and breast cancer.