MAPK8 and schizophrenia: c-Jun N-terminal kinase (JNK) signaling plays a key role in synaptic plasticity and neuronal communication.1 In humans, mutations in JNK genes lead to intellectual disability.2 We have identified a common variant in the MAP2K7 gene (encoding MAP kinase kinase 7 (MAP2K7), which activates JNKs) that shows a strong association with schizophrenia (ScZ).3 Genes in this signaling pathway are independently associated with ScZ (supplementary figure S1).4,5 Hence, strong evidence implicates the pathways modulated by MAP2K7 in ScZ.