GCG and Hypoglycemia: Based on American Diabetes Association (ADA) clinical practice guidelines, glucagon should be prescribed for all individuals at increased risk of clinically significant hypoglycemia defined as blood glucose <54 mg/dL (3.0 mmol/L).10 The currently approved glucagon emergency kits (GEKs) for severe hypoglycemia rescue contain lyophilized powder formulations of glucagon in a vial that require manual reconstitution with an aqueous diluent in a syringe format at time of use due to the instability of glucagon peptide in solution.