Severe hypoglycemia is a major concern of patients with diabetes and their caregivers, and when undertreated, episodes can lead to coma, seizures, and occasionally death.1–4 Hypoglycemic episodes among patients with both type 1 and type 2 diabetes are associated with an economic and emotional burden,5–7 with a substantial proportion of patients expressing fears or worry about the occurrence of hypoglycemia.8 Caregivers of persons with diabetes may also experience distress and feel unable to adequately undertake the administration of glucagon, especially during an emergency situation.9 The gene discussed is GCG; the disease is diabetes mellitus.