THBS1 and cancer: KMT2C which mainly induces H3K4me1 at gene enhances, its coding gene mutated recurrently in cancers.39 In single lesion CRCLM, mutated KMT2C weakened cell migration, affected genome stability and cell proliferation through abnormal THBS1, KAT2B and proliferation inhibitors like GATA1 and KAT2B40, 41, 42 (Figure 5A).