TLR4 and neoplasm: It is the only TLR that triggers 2 parallel downstream signaling pathways.24, 25 Some exogenous or endogenous ligands of TLR4 have also been assessed for use in tumor therapy.26 Monophosphoryl lipid A, a derivative of lipopolysaccharide (LPS), has been used as an adjuvant with Cervarix® in the prophylaxis of HPV‐associated cervical cancer.