Other derivatives of LPS and TLR4 agonists such as OM174 and E6020 have also been developed.27, 28, 29 Some endogenous agonists of TLR4 have been tested for anticancer activity; for example, recombinant HSP70 protein has been used as a vaccine against chronic myeloid leukemia in a phase I trial.30, 31. The gene discussed is TLR4; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.