There is increasing evidence that TLR4 is not only expressed on immune cells, but also on a large number of tumor types.41, 42 Because TLR4 expression by tumor cells may promote their own proliferation, survival, or even immunosuppression, activation of TLR4 is seen as a “double‐edged sword” in terms of therapeutic effects.43 Since specific antitumor immune responses are beneficial for tumor therapy, ways to specifically harness the antitumor effects of TLR4 stimulation need to be further explored. The gene discussed is TLR4; the disease is neoplasm.