Combined with these signals, it promotes cell growth by phosphorylating substrates to enhance anabolism (such as mRNA translation and lipid synthesis) or to limit catabolism (such as autophagy).37 Inhibition of the mTOR pathway enhances cell cycle arrest, inhibits proliferation, and promotes the autophagy of damaged tumor cells and even their apoptosis.38 The possibility exists that this is associated with the synergistic effect of VP‐16 and RAD001. This evidence concerns the gene MTOR and neoplasm.