BBC3 and cancer: puma induces mitochondrial dysfunction and caspase activation, and thus mediates cell death signals.30 Because of that, puma has been considered as a promising drug target for cancer therapy.31, 32 The present work revealed that KDM2B transcriptionally reduced the expression of p21 and puma via binding with the promoters of these two genes, indicating p21 and puma are two downstream effectors of KDM2B.